Cellular pharmacology of N,N-dimethyl daunorubicin and N,N-dimethyl adriamycin.

animal tumors (17)@and are less cardiotoxic in rabbits than are DNA and ADA.3 Although pharmacological studies of N-acet ylated, N-formylated, and N-trifluoroacetylated anthracycline antibiotics have been described, N-alkylated compounds have not been investigated. Since the cellular pharmacology of these compounds was undefined, we compared them to each other as well as to their parent compounds with regard to cellular drug accumulation, metabolism, disposition, and in vitro inhi bition of macromolecular biosynthesis.